I think WWDC this year will be the conference of the year.

They're gonna launch...

Definites:
1) The iPhone
2) OSX 10.5 (which is, to be fair, pretty good)
3) iWork 07
4) iLife 07

Possibles:

5) Probably a new iPod with touchscreen controls

6) Hopefully a new iMac (it's the oldest of their product lines)

7) Universal Binary of for CS3 Photoshop

and I'm sure there are a few others, but the first 4 are pretty much definites.